Detalhe da pesquisa
1.
Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters.
J Antimicrob Chemother
; 79(1): 172-178, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37995258
2.
A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection.
J Virol
; 96(16): e0075822, 2022 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35924921
3.
SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging.
Nat Chem Biol
; 17(2): 222-228, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33093684
4.
Synthesis of new 3-acetyl-1,3,4-oxadiazolines combined with pyrimidines as antileishmanial and antiviral agents.
Mol Divers
; 27(5): 2147-2159, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36251201
5.
Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
J Am Chem Soc
; 144(7): 2905-2920, 2022 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35142215
6.
Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: Evaluation of 5676 Phase 1 Passed Structures.
J Med Virol
; 94(7): 3101-3111, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35229317
7.
A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses.
PLoS Biol
; 17(6): e3000281, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31185007
8.
Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives.
J Mol Struct
; : 134135, 2022 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36101881
9.
Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors.
Molecules
; 28(1)2022 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36615354
10.
Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication.
Molecules
; 27(3)2022 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35164317
11.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33813272
12.
In vitro activity of itraconazole against SARS-CoV-2.
J Med Virol
; 93(7): 4454-4460, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33666253
13.
Discovery of novel furo[2,3-d]pyrimidin-2-one-1,3,4-oxadiazole hybrid derivatives as dual antiviral and anticancer agents that induce apoptosis.
Arch Pharm (Weinheim)
; 354(10): e2100146, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34128255
14.
Chemical Evolution of Antivirals Against Enterovirus D68 through Protein-Templated Knoevenagel Reactions.
Angew Chem Int Ed Engl
; 60(24): 13294-13301, 2021 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33749121
15.
Rational modifications, synthesis and biological evaluation of new potential antivirals for RSV designed to target the M2-1 protein.
Bioorg Med Chem
; 28(8): 115401, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32143992
16.
New HSV-1 Anti-Viral 1'-Homocarbocyclic Nucleoside Analogs with an Optically Active Substituted Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety.
Molecules
; 24(13)2019 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31277334
17.
Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.
J Antimicrob Chemother
; 73(7): 1823-1829, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29596680
18.
Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.
Bioorg Med Chem Lett
; 25(15): 2923-6, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048809
19.
Formation of a quaternary complex of HIV-1 reverse transcriptase with a nucleotide-competing inhibitor and its ATP enhancer.
J Biol Chem
; 288(24): 17336-46, 2013 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23598281
20.
Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.
Antimicrob Agents Chemother
; 58(8): 4875-84, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24841269